GET IN TOUCH:

Office

Tel: (404) 727-3729

FAX: (404) 727-5408

Email: peng.jin@emory.edu

Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Rm 323
Atlanta, GA 30322

Laboratory

Tel: (404) 727-7564 (Main Lab)

(404) 712-0796

(404) 727-3787 (Fly Lab)

FAX: (404) 727-5408

Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Room 325.1 and 355
Atlanta, GA 30322

© 2019 - Peng Jin Lab

CONTACT US:

image003.jpg

Tet-mediated epigenetic modulation in development and diseases

Cytosine methylation serves as a critical epigenetic mark by modifying DNA-protein interactions that influence transcriptional states and cellular identity. 5-methylcytosine (5mC) has generally been viewed as a stable covalent modification to DNA; however, the fact that 5-mC can be enzymatically modified to 5-hydroxymethylcytosine (5hmC) by Tet family proteins through Fe(II) a-KG-dependent hydroxylation gives a new perspective on the previously observed plasticity in 5mC-dependent regulatory processes.

 

Over the past several years, we have explored the roles of Tet-mediated epigenetic modulation in gene regulation, genomic stability, and tumorigenesis; and identified multiple proteins that could interact with Tet proteins, including RNA-binding protein Lin28 and Foxo3a

Featured Papers

01

Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P*, Song H*. (2016). Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell, 61, 153-160. (*: Co-Corresponding authors) PMC4779955

02

Yao, B. and Jin, P. (2014) Unlocking epigenetic codes in neurogenesis. Genes & Development, 28, 1253-1271.  PMC4066397

03

Li X, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P. (2017) Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications, 8:15903. PMC5493768

04

Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, Li Z, Wang Z, Chen J, Miao Z, Xin N, Huang L, Allen EG, Wu H, Xu X, Jin P. (2018) Distinct roles of Ten-eleven translocation protein 1 and 2 in response to environmental stress. Cell Reports, 25: 3194-3203.

juan1.png