Tet-mediated epigenetic modulation in development and diseases
Cytosine methylation serves as a critical epigenetic mark by modifying DNA-protein interactions that influence transcriptional states and cellular identity. 5-methylcytosine (5mC) has generally been viewed as a stable covalent modification to DNA; however, the fact that 5-mC can be enzymatically modified to 5-hydroxymethylcytosine (5hmC) by Tet family proteins through Fe(II) a-KG-dependent hydroxylation gives a new perspective on the previously observed plasticity in 5mC-dependent regulatory processes.
Over the past several years, we have explored the roles of Tet-mediated epigenetic modulation in gene regulation, genomic stability, and tumorigenesis; and identified multiple proteins that could interact with Tet proteins, including RNA-binding protein Lin28 and Foxo3a
Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P*, Song H*. (2016). Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell, 61, 153-160. (*: Co-Corresponding authors) PMC4779955
Yao, B. and Jin, P. (2014) Unlocking epigenetic codes in neurogenesis. Genes & Development, 28, 1253-1271. PMC4066397
Li X, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P. (2017) Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications, 8:15903. PMC5493768
Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, Li Z, Wang Z, Chen J, Miao Z, Xin N, Huang L, Allen EG, Wu H, Xu X, Jin P. (2018) Distinct roles of Ten-eleven translocation protein 1 and 2 in response to environmental stress. Cell Reports, 25: 3194-3203.