In recent years, increasing evidence indicates that multiple neurodevelopmental, neurodegenerative, and psychiatric disorders are caused, in part, by aberrant epigenetic modifications. We have examined the dynamic DNA modifications during neurodevelopment and aging, and their roles in the pathogenesis of human diseases.


Using the technology that we developed, we generated the first genome-wide maps of 5hmC during brain development, providing a detailed epigenomic view of regulated 5hmC in the CNS. Our analyses suggest that 5hmC-mediated epigenetic regulation may broadly impact brain development, and its dysregulation could contribute to autism.


Besides autism, our recent works have also linked 5hmC and Tet proteins to multiple neurological disorders, including fragile X-related disorders, ischemic brain injury and Alzheimer’s diseases.

Featured Papers

Szulwach, K.E., Li, X., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., Upadhyay, A.K., Gearing, M., Levey, A.I., Vasanthakumar, A., Godley, L.A., Chang, Q., Cheng, X., He, C. and Jin, P. (2011) 5-hydroxymethylcytosine-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nature Neuroscience, 14: 1607-1616.  PMC3292193


Yao, B., Lin, L., Street, R.C., Zalewski, Z.A., Galloway, J.N., Wu, H., Nelson, D.L., and Jin, P. (2013) Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. Human Molecular Genetics, 23: 1095-1107.  PMC3900112


Yao B, Cheng Y, Wang Z, Li Y, Chen L, Huang L, Zhang W, Chen D, Wu H, Tang B and Jin P. (2017) DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress. Nature Communications, 8: 1122. PMC5654764


Yao B, Li, Y., Wang Z, Chen L, Poidevin M, Zhang C, Lin L, Wang F, Bao H, Jiao B, Lim J, Cheng Y, Huang L, Philips BL, Xu T, Duan R, Moberg KH, Wu H, Jin P (2018) Active N6-Methyladenine demethylation by DMAD regulates gene expression by coordinating with Polycomb protein in neurons. Molecular Cell, 71: 848-857. PMC6136845





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Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Rm 323
Atlanta, GA 30322


Tel: (404) 727-7564 (Main Lab)

(404) 712-0796

(404) 727-3787 (Fly Lab)

FAX: (404) 727-5408

Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Room 325.1 and 355
Atlanta, GA 30322

© 2019 - Peng Jin Lab