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MicroRNAs and Human Diseases

MicroRNAs (miRNAs) are endogenous and non-coding single-stranded RNAs of ~22 nucleotides, many of which are evolutionarily conserved. MiRNAs could orchestrate neuronal development and plasticity by modulating complex gene networks. The perturbation of miRNA expression could potentially contribute to the etiology of human diseases.


Over the last 15 years, we have revealed the role of miRNAs in neuropsychiatric disorders, including fragile X syndrome, Rett syndrome, autism and schizophrenia.

Featured Papers


Szulwach K. E., Li, X., Smrt, R.D., Li, Y., Luo, Y., Lin, L., Satistevan, N.J., Li, W. Zhao, X., and Jin, P. (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. Journal of Cell Biology, 189, 127-141.  PMC2854370


Jin, P., Zarnescu, D.C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T.A., Nelson, D.L., Moses, K., and Warren, S.T. (2004). Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neuroscience, 7, 113-117.


Cheng Y, Wang ZM, Tan W, Wang X, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D, Teng ZQ, Jin P. (2018) Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience, Epub 2018/11/07. PubMed PMID: 30397325.

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