GET IN TOUCH:

Office

Tel: (404) 727-3729

FAX: (404) 727-5408

Email: peng.jin@emory.edu

Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Rm 323
Atlanta, GA 30322

Laboratory

Tel: (404) 727-7564 (Main Lab)

(404) 712-0796

(404) 727-3787 (Fly Lab)

FAX: (404) 727-5408

Department of Human Genetics
Emory University School of Medicine
615 Michael Street, Room 325.1 and 355
Atlanta, GA 30322

© 2019 - Peng Jin Lab

CONTACT US:

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MicroRNAs and Human Diseases

MicroRNAs (miRNAs) are endogenous and non-coding single-stranded RNAs of ~22 nucleotides, many of which are evolutionarily conserved. MiRNAs could orchestrate neuronal development and plasticity by modulating complex gene networks. The perturbation of miRNA expression could potentially contribute to the etiology of human diseases.

 

Over the last 15 years, we have revealed the role of miRNAs in neuropsychiatric disorders, including fragile X syndrome, Rett syndrome, autism and schizophrenia.

Featured Papers

01

Szulwach K. E., Li, X., Smrt, R.D., Li, Y., Luo, Y., Lin, L., Satistevan, N.J., Li, W. Zhao, X., and Jin, P. (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. Journal of Cell Biology, 189, 127-141.  PMC2854370

02

Jin, P., Zarnescu, D.C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T.A., Nelson, D.L., Moses, K., and Warren, S.T. (2004). Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neuroscience, 7, 113-117.

03

Cheng Y, Wang ZM, Tan W, Wang X, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D, Teng ZQ, Jin P. (2018) Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nature Neuroscience, Epub 2018/11/07. PubMed PMID: 30397325.

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